The technique explained in this article is really new to me: start with the most important content block and build the page around that block, navigation, side bars, everything.
So, if you were to start designing this page from scratch, you’d start here — with the message unit. The subject, the body, the metadata, the link and file attachment styles, etc. Only when that unit is complete would you begin to think about the second most critical element on the page
Jason Fried
The post was published in 2004 but seems still relevant as they posted a pointer to another blog “To-Done” where Britt Parrot writes about a similar technique to get a web design project going: Starting in the middle
And flingmedia uses a similar technique to do audience research.
The idea of putting the focus on the main goal or most important block of the page is interesting enough to try. It certainly worked for basecamp and other apps from 37signals and it is different then other techniques like a Page Description Diagram (PDD) that comes together after exensive research and discussion.